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CS-W001157 4
Total: USD 88.00

2,4-Dichloro-6-(trifluoromethyl)pyridine

  • CAS No. 39891-02-6

  • Cat. No. CS-0040112
  • Purity≥97%
  • MDL No.MFCD10698621
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-6-(trifluoromethyl)pyridine|CS-0040112

Structure of 39891-02-6

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Description

2,4-Dichloro-6-(trifluoromethyl)pyridine features a strongly electron-deficient pyridine core enhanced by orthogonal chlorine and trifluoromethyl substituents. This combination imparts high reactivity in cross-coupling processes and excellent stability under standard bench conditions. The molecule serves as a key building block for pharmaceutical intermediates and agrochemicals.

Application

2,4-Dichloro-6-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. The electron-deficient pyridine core exhibits high reactivity toward nucleophilic substitution, with the trifluoromethyl group enhancing metabolic stability and lipophilicity. Bench-stable and readily purified, it functions effectively in Suzuki, Stille, and Buchwald-Hartwig coupling protocols, facilitating rapid access to complex target molecules.

General Information

  • CAS No. 39891-02-6
  • Cat. No. CS-0040112
  • Purity ≥97%
  • MDL No. MFCD10698621
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂Cl₂F₃N
  • Molecular Weight 215.99
  • Synonym(s) None
  • SMILES FC(C1=CC(Cl)=CC(Cl)=N1)(F)F

Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.4072
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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