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CS-W001157 4
Total: USD 88.00

(2-Fluorobenzyl)methylamine

  • CAS No. 399-30-4

  • Cat. No. CS-W005782
  • Purity≥95%
  • MDL No.MFCD04629633

*For research and further manufacturing use only, not for direct human use.

(2-Fluorobenzyl)methylamine|CS-W005782

Structure of 399-30-4

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General Information

  • CAS No. 399-30-4
  • Cat. No. CS-W005782
  • Purity ≥95%
  • MDL No. MFCD04629633
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀FN
  • Molecular Weight 139.17
  • Synonym(s) N-Methyl-2-fluorobenzylamine
  • SMILES CNCC1=CC=CC=C1F

Description

(2-Fluorobenzyl)methylamine features a fluorinated aromatic ring linked to a primary amine-bearing alkyl chain, delivering enhanced metabolic stability and improved membrane permeability. This combination enables efficient integration into bioactive scaffolds for medicinal chemistry applications.

Application

(2-Fluorobenzyl)methylamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through amine coupling and functionalization. Its dual aryl and alkyl amine functionality offers favorable reactivity in standard peptide and heterocyclic syntheses, while the ortho-fluoro substituent enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified, it functions effectively in both solution-phase and solid-phase workflows.

Synthesis

  • Route1
    • null|null
      1159505-77-7
    • ~87%
    • In-stock
      (2-Fluorobenzyl)methylamine|CS-W005782
      399-30-4

    References

    • The Scripps Research Insitiute Patent: US2012/59179 A1, 2012 ; Location in patent: Page/Page column 17 ;
  • Route2
    • null|null
      446-48-0
    • null|null
      74-89-5
    • ~84%
    • In-stock
      (2-Fluorobenzyl)methylamine|CS-W005782
      399-30-4

    References

    • MITSUBISHI TANABE PHARMA CORPORATION Patent: US2012/196824 A1, 2012 ;
  • Route3
    • Tert-butyl (2-fluorobenzyl)carbamate|CS-0535668
      153903-21-0
    • ~%
    • In-stock
      (2-Fluorobenzyl)methylamine|CS-W005782
      399-30-4

    References

    • GRAFFINITY PHARMACEUTICALS AG Patent: WO2005/95343 A1, 2005 ; Location in patent: Page/Page column 40 ; WO 2005/095343 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H412
Precautionary Statements : P210-P264-P273-P280-P302+P352-P362-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.5451
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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