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Structure of 400-97-5
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1-Iodo-2-nitro-4-(trifluoromethyl)benzene features a trifluoromethyl group and a nitro substituent positioned ortho to the iodine, creating a highly electron-deficient aromatic ring. This combination enables efficient palladium-catalyzed cross-coupling reactions under standard conditions, with the iodo handle facilitating reliable C–C bond formation. The molecule exhibits bench-stable handling characteristics and compatibility with diverse reaction media.
1-Iodo-2-nitro-4-(trifluoromethyl)benzene serves as a versatile building block in cross-coupling chemistry, enabling efficient construction of biaryl architectures under palladium catalysis. The iodide group facilitates reliable Suzuki, Stille, and Negishi reactions, while the nitro and trifluoromethyl functionalities provide strong electron-withdrawing character and enhanced metabolic stability. This combination supports precise tuning of electronic properties in pharmaceutical and agrochemical scaffolds, with excellent bench stability and straightforward purification via standard chromatographic methods.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: