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Structure of 400-99-7
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2-Nitro-4-(trifluoromethyl)phenol features a para-nitro group flanked by a trifluoromethyl substituent on the aromatic ring, delivering high electron deficiency and enhanced stability. This configuration enables efficient coupling in cross-coupling reactions and facilitates direct functionalization in synthetic sequences. The molecule exhibits robust performance under standard bench conditions and serves as a key intermediate in pharmaceutical and agrochemical synthesis.
2-Nitro-4-(trifluoromethyl)phenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of functionalized heterocycles. Its electron-deficient aromatic core facilitates nucleophilic substitution and palladium-catalyzed coupling reactions. The molecule exhibits good bench stability and can be readily purified via recrystallization, making it well-suited for scalable synthetic workflows requiring high functional group tolerance.
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GHS Pictogram :
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GHS No : GHS05,GHS07,GHS09
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Signal Word : Danger
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UN#: 3082
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H317-H318-H410
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Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501
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Lot numbers can be found on the outside label of a product: