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CS-W001157 4
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4-Fluorobenzenesulfonamide

  • CAS No. 402-46-0

  • Cat. No. CS-0072364
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Fluorobenzenesulfonamide|CS-0072364

Structure of 402-46-0

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Description

4-Fluorobenzenesulfonamide features a fluorinated aromatic ring paired with a sulfonamide group, delivering enhanced metabolic stability and improved solubility compared to non-fluorinated analogs. This combination enables efficient integration into bioactive molecules, particularly in kinase inhibitor scaffolds and pharmaceutical lead optimization.

Application

4-Fluorobenzenesulfonamide serves as a versatile building block in medicinal chemistry, enabling the construction of sulfonamide-containing heterocycles and bioactive scaffolds. Its fluorinated aryl group enhances metabolic stability and modulates electronic properties, while the sulfonamide moiety offers strong hydrogen-bonding capacity and favorable pharmacokinetic profiles. The compound exhibits excellent bench stability, facilitates straightforward purification, and demonstrates broad functional group tolerance in standard coupling reactions.

General Information

  • CAS No. 402-46-0
  • Cat. No. CS-0072364
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO₂S
  • Molecular Weight 175.18
  • Synonym(s) p-Fluorobenzenesulfonamide
  • SMILES O=S(C1=CC=C(F)C=C1)(N)=O

Computational Chemistry Data

  • TPSA   60.16
  • LogP   0.4731
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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