2-Aminothiazole-4-carboxylic acid

Name: 2-Aminothiazole-4-carboxylic acid
Brand: ChemScene
Availability: InStock
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CAS No. 40283-41-8
Cat. No. CS-W023136
Purity≥98%
MDL No.MFCD00859429

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Aminothiazole-4-carboxylic acid|CS-W023136

Structure of 40283-41-8

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General Information

CAS No. 40283-41-8
Cat. No. CS-W023136
Purity ≥98%
MDL No. MFCD00859429
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₄N₂O₂S
Molecular Weight 144.15
Synonym(s) Aminothiazole-4-carboxylate, 2-
SMILES Nc1nc(cs1)C(O)=O

Description

2-Aminothiazole-4-carboxylic acid features a fused thiazole ring bearing both amino and carboxylic acid functionalities, enabling direct incorporation into bioactive scaffolds. This dual functionality supports hydrogen bonding and metal coordination, enhancing binding affinity in medicinal chemistry applications. The compound exhibits robust stability under standard bench conditions and integrates readily into peptide and heterocyclic syntheses.

Application

2-Aminothiazole-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds through coupling reactions and cyclization protocols. Its dual functionality—amine and carboxylic acid groups—facilitates efficient derivatization, while its bench-stable crystalline form supports straightforward handling and purification. Widely employed in API research, it functions as a key intermediate for thiazole-based bioactive molecules.

Synthesis

Route1
- In-stock
  
  5398-36-7
- ~87%
- In-stock
  
  40283-41-8
References
- Mitsui Chemicals Agro, Inc. Patent: EP2325165 A1, 2011 ; Location in patent: Page/Page column 460 ;
Route2
- 118452-04-3
- ~97%
- In-stock
  
  40283-41-8
References
- F. HOFFMANN-LA ROCHE AG; GOODNOW JR., Robert Alan; HAMILTON, Matthew Michael; KOWALCZYK, Agnieszka; SIDDURI, Achyutharao Patent: WO2013/110578 A1, 2013 ; Location in patent: Page/Page column 47 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 76.21
LogP 0.4235
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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2-Aminothiazole-4-carboxylic acid

CAS No. 40283-41-8

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