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CS-W001157 4
Total: USD 88.00

4-Amino-1-(methylsulfonyl)piperidine

  • CAS No. 402927-97-3

  • Cat. No. CS-W003359
  • Molecule weight178.25
  • Purity≥97%
  • MDL No.MFCD06805736

*For research and further manufacturing use only, not for direct human use.

4-Amino-1-(methylsulfonyl)piperidine|CS-W003359

Structure of 402927-97-3

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General Information

  • CAS No. 402927-97-3
  • Cat. No. CS-W003359
  • Purity ≥97%
  • MDL No. MFCD06805736
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄N₂O₂S
  • Molecular Weight 178.25
  • Synonym(s) 4-Amino-1-methanesulfonylpiperidine
  • SMILES NC1CCN(CC1)S(=O)(=O)C

Application

4-Amino-1-(methylsulfonyl)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard amine functionalization and coupling reactions. Its methylsulfonyl group enhances solubility and metabolic stability, while the primary amine facilitates rapid derivatization. Bench-stable and compatible with common protecting group strategies, it functions effectively in peptide coupling, Ugi-type reactions, and transition-metal-catalyzed transformations.

Synthesis

  • Route1
    • Benzyl (1-(methylsulfonyl)piperidin-4-yl)carbamate|CS-0313540
      402927-96-2
    • ~%
    • In-stock
      4-Amino-1-(methylsulfonyl)piperidine|CS-W003359
      402927-97-3

    References

    • US2003/232847 A1, ; Page 15 ; US 20030232847 A1
  • Route2
    • tert-Butyl (1-(methylsulfonyl)piperidin-4-yl)carbamate|CS-0154402
      287953-38-2
    • ~%
    • In-stock
      4-Amino-1-(methylsulfonyl)piperidine|CS-W003359
      402927-97-3

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 22 p. 6549 - 6560
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 22 p. 6549 - 6560

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.4
  • LogP   -0.6309
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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