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CS-W001157 4
Total: USD 88.00

5-Chloro-2-iodo-1,3-dimethylbenzene

  • CAS No. 404337-42-4

  • Cat. No. CS-0035645
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-iodo-1,3-dimethylbenzene|CS-0035645

Structure of 404337-42-4

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Description

5-Chloro-2-iodo-1,3-dimethylbenzene features a dual-heteroatom substitution pattern on a methylated benzene core, enabling selective cross-coupling reactions. The electron-deficient aryl iodide moiety facilitates efficient palladium-catalyzed transformations, while the chloro group offers orthogonal reactivity. This bench-stable derivative combines enhanced functional group tolerance with predictable regiochemistry in synthetic sequences.

Application

5-Chloro-2-iodo-1,3-dimethylbenzene serves as a versatile diaryl building block for palladium-catalyzed cross-coupling reactions. The orthogonal reactivity of chlorine and iodine enables sequential functionalization, while the methyl groups enhance solubility and stability. This compound facilitates efficient access to substituted biaryls and heterocyclic scaffolds in medicinal chemistry and materials science applications.

General Information

  • CAS No. 404337-42-4
  • Cat. No. CS-0035645
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈ClI
  • Molecular Weight 266.51
  • Synonym(s) 5-Chloro-2-iodo-M-xylene
  • SMILES CC1=C(C(=CC(=C1)Cl)C)I

Computational Chemistry Data

  • TPSA   0
  • LogP   3.56144
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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