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CS-W001157 4
Total: USD 88.00

4-Methoxypiperidine

  • CAS No. 4045-24-3

  • Cat. No. CS-0040128
  • Purity≥98%
  • MDL No.MFCD04115010

*For research and further manufacturing use only, not for direct human use.

4-Methoxypiperidine|CS-0040128

Structure of 4045-24-3

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General Information

  • CAS No. 4045-24-3
  • Cat. No. CS-0040128
  • Purity ≥98%
  • MDL No. MFCD04115010
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃NO
  • Molecular Weight 115.17
  • Synonym(s) 4-Methoxy-piperidin
  • SMILES COC1CCNCC1

Description

4-Methoxypiperidine delivers a robust, electron-rich nitrogen heterocycle ideal for medicinal chemistry applications. This bench-stable, moisture-tolerant scaffold integrates readily into diverse molecular architectures, enhancing solubility and metabolic stability in bioactive compounds.

Application

4-Methoxypiperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through straightforward functionalization. Its methoxy group enhances solubility and modulates basicity, while the piperidine core provides a rigid yet tunable scaffold for ligand design. The compound exhibits excellent bench stability, facilitates purification by standard chromatographic methods, and participates reliably in common coupling reactions, making it a practical choice for lead optimization and API synthesis.

Synthesis

  • Route1
    • null|null
      553672-12-1
    • ~99%
    • In-stock
      4-Methoxypiperidine|CS-0040128
      4045-24-3

    References

    • TANABE SEIYAKU CO., LTD. Patent: WO2007/46550 A1, 2007 ; Location in patent: Page/Page column 116-117 ; WO 2007/046550 A1
  • Route2
    • null|null
      141047-49-6
    • ~33%
    • In-stock
      4-Methoxypiperidine|CS-0040128
      4045-24-3

    References

    • F. HOFFMANN-LA ROCHE AG Patent: WO2007/19884 A1, 2007 ; Location in patent: Page/Page column 45 ; WO 2007/019884 A1
  • Route3

    References

    • Irfan, Muhammed; Petricci, Elena; Glasnov, Toma N.; Taddei, Maurizio; Kappe, C. Oliver European Journal of Organic Chemistry, 2009 , # 9 p. 1327 - 1334

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.3848
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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