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Structure of 407-14-7
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1-Bromo-4-(trifluoromethoxy)benzene on treatment with lithium diisopropylamide (LIDA) at -100C gives 5-bromo-2-(trifluoromethoxy)phenyllithium and at -75C it eliminates lithium bromide, thus generating 1,2-dehydro-4-(trifluoromethoxy)benzene.1-Bromo-4-(trifluoromethoxy)benzene was used in the synthesis of 4-{[4-[(2-ethylhexyloxy)-6-(4-morpholinylmethyl)-4-trifluoromethyl][1,1-biphenyl]-3-yl]methyl}morpholine.
1-Bromo-4-(trifluoromethoxy)benzene serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions such as Suzuki, Stille, and Negishi couplings. The trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient synthesis of functionalized aryl scaffolds and complex heterocycles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: