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CS-W001157 4
Total: USD 88.00

6-Quinolinecarboxaldehyde

  • CAS No. 4113-04-6

  • Cat. No. CS-W018545
  • Molecule weight157.17
  • Purity≥98%
  • MDL No.MFCD00805836

*For research and further manufacturing use only, not for direct human use.

6-Quinolinecarboxaldehyde|CS-W018545

Structure of 4113-04-6

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General Information

  • CAS No. 4113-04-6
  • Cat. No. CS-W018545
  • Purity ≥98%
  • MDL No. MFCD00805836
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇NO
  • Molecular Weight 157.17
  • Synonym(s) Quinoline-6-carbaldehyde
  • SMILES O=CC1=CC=C2N=CC=CC2=C1

Description

6-Quinolinecarboxaldehyde features a quinoline scaffold with an aldehyde group at the 6-position, enabling direct incorporation into conjugated systems. This electron-deficient heterocycle serves as a key building block for pharmaceutical intermediates and ligands in transition metal catalysis. The aldehyde functionality offers high reactivity in condensation and coupling reactions under standard conditions.

Application

6-Quinolinecarboxaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds and functionalized quinoline derivatives. Its aldehyde functionality facilitates nucleophilic additions, condensations, and transition-metal-catalyzed couplings under standard reaction conditions. The molecule exhibits good bench stability and compatibility with common protecting groups, making it suitable for iterative synthesis workflows in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. Patent: WO2004/7491 A1, 2004 ; Location in patent: Page 56 ;
  • Route2
    • null|null
      91-62-3
    • ~71%
    • In-stock
      6-Quinolinecarboxaldehyde|CS-W018545
      4113-04-6

    References

    • Tulyaganov, T. S.; Ibragimov, A. A.; Yunusov, S. Yu. Chemistry of Natural Compounds, 1982 , vol. 18, p. 604 - 605 Khimiya Prirodnykh Soedinenii, 1982 , vol. 18, # 5 p. 638 - 640
  • Route3

    References

    • Felpin, Francois-Xavier; Bertrand, Marie-Jo; Lebreton, Jacques Tetrahedron, 2002 , vol. 58, # 37 p. 7381 - 7389

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.0473
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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