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CS-W001157 4
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Ethyl 6-(hydroxymethyl)picolinate

  • CAS No. 41337-81-9

  • Cat. No. CS-0038369
  • Purity≥97%
  • MDL No.MFCD09750009
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Ethyl 6-(hydroxymethyl)picolinate|CS-0038369

Structure of 41337-81-9

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Description

Ethyl 6-(hydroxymethyl)picolinate features a hydroxymethyl group at the 6-position of the picolinate scaffold, enabling direct functionalization for bioconjugation or derivatization. This bench-stable ester integrates readily into synthetic sequences requiring polar, oxygen-rich side chains. The para-hydroxyalkyl moiety enhances solubility and provides a handle for further chemical modification.

Application

Ethyl 6-(hydroxymethyl)picolinate serves as a versatile building block for heterocyclic synthesis, enabling efficient access to bioactive scaffolds through standard functional group transformations. The pendant hydroxymethyl group facilitates oxidation to carboxylic acid, reduction to alcohol, or derivatization via Mitsunobu and Williamson ether reactions. Its stability under routine bench conditions and compatibility with common protecting group strategies make it a practical choice for medicinal chemistry campaigns requiring picolinic acid derivatives.

General Information

  • CAS No. 41337-81-9
  • Cat. No. CS-0038369
  • Purity ≥97%
  • MDL No. MFCD09750009
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₃
  • Molecular Weight 181.19
  • Synonym(s) Ethyl 6-(hydroxymethyl)pyridine-2-carboxylate
  • SMILES CCOC(=O)C1=CC=CC(=N1)CO

Computational Chemistry Data

  • TPSA   59.42
  • LogP   0.7506
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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