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CS-W001157 4
Total: USD 88.00

2-Bromo-4-fluoro-5-methoxyaniline

  • CAS No. 420786-92-1

  • Cat. No. CS-0159333
  • Purity≥98%
  • MDL No.MFCD09800756
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Bromo-4-fluoro-5-methoxyaniline|CS-0159333

Structure of 420786-92-1

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Description

This brominated aniline derivative features a methoxy group at the 5-position and fluorine at the 4-position, enabling selective coupling reactions in pharmaceutical synthesis. The electron-withdrawing halogens enhance reactivity while maintaining stability under standard conditions.

Application

2-Bromo-4-fluoro-5-methoxyaniline serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed coupling reactions. Its orthogonal functional groups—bromine for cross-coupling, fluoro for electrophilic substitution, and methoxy for directing effects—facilitate precise molecular diversification. The compound exhibits excellent bench stability and compatibility with standard purification protocols, making it well-suited for scalable synthesis and API intermediate development.

General Information

  • CAS No. 420786-92-1
  • Cat. No. CS-0159333
  • Purity ≥98%
  • MDL No. MFCD09800756
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BrFNO
  • Molecular Weight 220.04
  • Synonym(s) Benzenamine, 2-bromo-4-fluoro-5-methoxy-
  • SMILES NC1=CC(OC)=C(F)C=C1Br

Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.179
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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