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CS-W001157 4
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2-Chloro-3-(hydroxymethyl)pyridine

  • CAS No. 42330-59-6

  • Cat. No. CS-D0980
  • Purity≥98%
  • MDL No.MFCD01935961

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-(hydroxymethyl)pyridine|CS-D0980

Structure of 42330-59-6

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General Information

  • CAS No. 42330-59-6
  • Cat. No. CS-D0980
  • Purity ≥98%
  • MDL No. MFCD01935961
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClNO
  • Molecular Weight 143.57
  • Synonym(s) 2-Choro-3-(hydroxymethyl)pyridine
  • SMILES OCC1=CC=CN=C1Cl

Description

2-Chloro-3-(hydroxymethyl)pyridine features a reactive chloropyridine core paired with a pendant hydroxymethyl group, enabling seamless functionalization in synthetic transformations. This bench-stable derivative integrates readily into heterocyclic scaffolds and serves as a key intermediate in medicinal chemistry and agrochemical development.

Application

2-Chloro-3-(hydroxymethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling efficient functionalization at the pyridine ring via nucleophilic substitution. The chloro group exhibits high reactivity toward amines, thiols, and other nucleophiles under mild conditions, while the hydroxymethyl moiety provides a handle for oxidation, protection, or further derivatization. Its bench-stable nature and compatibility with standard synthetic workflows make it ideal for constructing heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.2273
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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