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CS-W001157 4
Total: USD 88.00

Diethyl 2-cyclopropylmalonate

  • CAS No. 42392-68-7

  • Cat. No. CS-0038375
  • Purity≥97%
  • MDL No.MFCD25963390

*For research and further manufacturing use only, not for direct human use.

Diethyl 2-cyclopropylmalonate|CS-0038375

Structure of 42392-68-7

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General Information

  • CAS No. 42392-68-7
  • Cat. No. CS-0038375
  • Purity ≥97%
  • MDL No. MFCD25963390
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₆O₄
  • Molecular Weight 200.23
  • Synonym(s) Diethyl cyclopropylmalonate
  • SMILES CCOC(=O)C(C1CC1)C(=O)OCC

Description

Diethyl 2-cyclopropylmalonate features a cyclopropyl-substituted malonate core, delivering high reactivity in enolate-mediated C–C bond formations. The strained cyclopropyl ring enhances electrophilic character at the α-position, enabling efficient alkylation under mild conditions. This bench-stable derivative integrates readily into complex molecule synthesis, particularly in stereoselective routes to functionalized cyclic scaffolds.

Application

Diethyl 2-cyclopropylmalonate serves as a versatile building block in synthetic organic chemistry, enabling the efficient construction of cyclopropyl-substituted carboxylic acid derivatives. Its malonate functionality facilitates facile alkylation and decarboxylation sequences, providing access to valuable synthons for medicinal chemistry and natural product synthesis. The cyclopropyl group imparts unique stereochemical and conformational constraints, enhancing its utility in targeted molecular design. The compound exhibits good bench stability and is amenable to standard purification protocols, making it well-suited for routine laboratory use.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330

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Computational Chemistry Data

  • TPSA   52.6
  • LogP   1.1388
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   5

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