methyl 2,6-dichloroisonicotinate

Name: methyl 2,6-dichloroisonicotinate
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CAS No. 42521-09-5
Cat. No. CS-W002219
Purity≥98%
MDL No.MFCD00044409

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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methyl 2,6-dichloroisonicotinate|CS-W002219

Structure of 42521-09-5

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Description

Methyl 2,6-dichloroisonicotinate is a bench-stable, electron-deficient heterocyclic ester featuring two chlorine substituents at the 2- and 6-positions of the pyridine ring. This configuration enhances reactivity in cross-coupling processes and facilitates incorporation into pharmaceutical intermediates. The methyl ester group enables straightforward derivatization under standard conditions.

Application

Methyl 2,6-dichloroisonicotinate serves as a versatile building block in medicinal chemistry and agrochemical synthesis. Its electron-deficient pyridine core enables efficient Suzuki-Miyaura and Buchwald-Hartwig couplings, while the ester functionality supports selective hydrolysis or derivatization. The ortho-dichloro substitution enhances reactivity in nucleophilic aromatic substitution and provides synthetic handles for further functionalization. Bench-stable and readily purified by flash chromatography, it functions reliably in multi-step syntheses of heterocyclic scaffolds and API intermediates.

General Information

CAS No. 42521-09-5
Cat. No. CS-W002219
Purity ≥98%
MDL No. MFCD00044409
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅Cl₂NO₂
Molecular Weight 206.03
Synonym(s) None
SMILES COC(=O)c1cc(Cl)nc(c1)Cl

Computational Chemistry Data

TPSA 39.19
LogP 2.175
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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methyl 2,6-dichloroisonicotinate

CAS No. 42521-09-5

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