Methyl 2-chloroisonicotinate

Name: Methyl 2-chloroisonicotinate
Brand: ChemScene
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CAS No. 58481-11-1
Cat. No. CS-W004976
Purity≥98%
MDL No.MFCD01765409

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 58481-11-1

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Description

Methyl 2-chloroisonicotinate is a bench-stable, moisture-tolerant heterocyclic ester featuring a chlorine atom at the 2-position of the pyridine ring. This electron-deficient scaffold integrates readily into synthetic sequences requiring selective functionalization. The methyl ester group enables straightforward derivatization, facilitating access to diverse bioactive molecules and pharmaceutical intermediates.

Application

Methyl 2-chloroisonicotinate serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution and coupling reactions. Its ortho-chloro functionality exhibits high reactivity toward amines, thiols, and organometallic reagents, facilitating rapid diversification. The methyl ester group supports selective transformations and downstream derivatization, while the compound demonstrates excellent bench stability and ease of purification in standard synthetic workflows.

General Information

CAS No. 58481-11-1
Cat. No. CS-W004976
Purity ≥98%
MDL No. MFCD01765409
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆ClNO₂
Molecular Weight None
Synonym(s) Methyl 2-Chloro-4-pyridinecarboxylate
SMILES C1=C(Cl)N=CC=C1C(OC)=O

Computational Chemistry Data

TPSA 39.19
LogP 1.5216
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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Methyl 2-chloroisonicotinate

CAS No. 58481-11-1

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