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CS-W001157 4
Total: USD 88.00

1-Methylpyrrolidine-2,3-dione

  • CAS No. 42599-26-8

  • Cat. No. CS-0139148
  • Molecule weight113.11
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Methylpyrrolidine-2,3-dione|CS-0139148

Structure of 42599-26-8

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General Information

  • CAS No. 42599-26-8
  • Cat. No. CS-0139148
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇NO₂
  • Molecular Weight 113.11
  • Synonym(s) 1-Methyl-2,3-Pyrrolidinedione
  • SMILES O=C1N(C)CCC1=O

Description

1-Methylpyrrolidine-2,3-dione delivers a highly reactive cyclic anhydride moiety ideal for amine coupling and protein modification. This bench-stable reagent features enhanced solubility in organic solvents and undergoes selective acylation under mild conditions. The methyl group confers improved stability without compromising reactivity, enabling efficient conjugation workflows in chemical biology and materials functionalization.

Application

1-Methylpyrrolidine-2,3-dione serves as a versatile dienophile in Diels-Alder reactions and functions as a stable, bench-ready building block for heterocyclic synthesis. Its electron-deficient diene system enables efficient cycloadditions with a range of dienes, facilitating rapid access to complex carbocyclic and heterocyclic scaffolds. The molecule exhibits excellent functional group tolerance and is amenable to straightforward purification, making it a practical choice for synthetic organic chemists developing pharmaceutical intermediates and natural product analogs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.38
  • LogP   -0.5824
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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