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CS-W001157 4
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Pivalohydrazide

  • CAS No. 42826-42-6

  • Cat. No. CS-0086980
  • Molecule weight116.16
  • Purity≥97%
  • MDL No.MFCD01310839

*For research and further manufacturing use only, not for direct human use.

Pivalohydrazide|CS-0086980

Structure of 42826-42-6

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General Information

  • CAS No. 42826-42-6
  • Cat. No. CS-0086980
  • Purity ≥97%
  • MDL No. MFCD01310839
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂N₂O
  • Molecular Weight 116.16
  • Synonym(s) Pivalic acid hydrazide
  • SMILES CC(C)(C)C(NN)=O

Description

Pivalohydrazide features a sterically hindered tert-butyl group adjacent to the hydrazide functional moiety, enhancing stability and reducing undesired side reactions. This robust scaffold enables reliable coupling in amide bond formation and facilitates the synthesis of complex hydrazine-based architectures under standard conditions.

Application

Pivalohydrazide serves as a stable, bench-ready hydrazide reagent for the selective formation of hydrazones and hydrazides under mild conditions. Its sterically hindered tert-butyl group enhances stability and minimizes side reactions, facilitating clean purification and compatibility with diverse functional groups. Widely used in heterocycle synthesis and as a building block in medicinal chemistry, it enables efficient construction of pyrazole and triazole scaffolds through established coupling protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   0.0224
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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