2,2,2-Trimethylacetamide

Name: 2,2,2-Trimethylacetamide
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 754-10-9
Cat. No. CS-W021470
Purity≥98%
MDL No.MFCD00008011

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

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Description

2,2,2-Trimethylacetamide is a sterically hindered amide featuring a bulky trimethylacetyl group. This structure imparts exceptional stability and low nucleophilicity, making it ideal for use in sensitive synthetic transformations. The molecule’s high boiling point and low water solubility enable efficient separation and purification workflows. It serves as a robust solvent and reaction medium under standard bench conditions.

Application

2,2,2-Trimethylacetamide serves as a stable, bench-friendly amide solvent and acylating agent, enabling efficient N-acylation reactions with excellent functional group tolerance. Its sterically hindered structure enhances hydrolytic stability and simplifies purification, making it well-suited for peptide coupling and heterocycle synthesis in medicinal chemistry workflows.

General Information

CAS No. 754-10-9
Cat. No. CS-W021470
Purity ≥98%
MDL No. MFCD00008011
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₁₁NO
Molecular Weight 101.15
Synonym(s) Trimethylacetamide, (Pivalamide)
SMILES O=C(N)C(C)(C)C

Computational Chemistry Data

TPSA 43.09
LogP 0.5178
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Other Classifications

Building Blocks Skeleton Fatty chain compounds

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2,2,2-Trimethylacetamide

CAS No. 754-10-9

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