4-Chloro-5-fluoro-2-nitroaniline

Name: 4-Chloro-5-fluoro-2-nitroaniline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 428871-64-1
Cat. No. CS-0042737
Purity≥96%
MDL No.MFCD12828238

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-5-fluoro-2-nitroaniline|CS-0042737

Structure of 428871-64-1

Size

Price

Quantity

* Please select Quantity before adding items.

Description

4-Chloro-5-fluoro-2-nitroaniline features a trifunctional aromatic core with electron-withdrawing nitro and halogen substituents, enabling direct coupling in cross-coupling and heterocycle synthesis. The ortho-halogen positions facilitate palladium-catalyzed transformations, while the nitro group serves as a handle for selective reduction or further functionalization. This scaffold offers high reactivity under standard conditions with excellent stability during storage and handling.

Application

4-Chloro-5-fluoro-2-nitroaniline serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its orthogonal reactivity profile—combining a nitro group for reduction and halogenation, along with a fluoro substituent—facilitates sequential functionalization. The compound exhibits good bench stability and is compatible with standard coupling reactions, simplifying purification and scale-up in API development workflows.

General Information

CAS No. 428871-64-1
Cat. No. CS-0042737
Purity ≥96%
MDL No. MFCD12828238
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClFN₂O₂
Molecular Weight 190.56
Synonym(s) 4-chloro-5-fluoro-2-nitro-phenylamine
SMILES NC1=CC(F)=C(Cl)C=C1[N+]([O-])=O

Computational Chemistry Data

TPSA 69.16
LogP 1.9695
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

4-Chloro-5-fluoro-2-nitroaniline sigma4-Chloro-5-fluoro-2-nitroaniline manufacturer4-Chloro-5-fluoro-2-nitroaniline price4-Chloro-5-fluoro-2-nitroaniline structure4-Chloro-5-fluoro-2-nitroaniline SDSbuy 4-Chloro-5-fluoro-2-nitroaniline4-Chloro-5-fluoro-2-nitroaniline supplier4-Chloro-5-fluoro-2-nitroaniline uses4-Chloro-5-fluoro-2-nitroaniline molecular weightprice of 4-Chloro-5-fluoro-2-nitroaniline4-Chloro-5-fluoro-2-nitroaniline chemical name formula of 4-Chloro-5-fluoro-2-nitroaniline

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Chloro-5-fluoro-2-nitroaniline

CAS No. 428871-64-1

Recommended Products