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CS-W001157 4
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3-Aminopyrazin-2(1H)-one

  • CAS No. 43029-19-2

  • Cat. No. CS-W019050
  • Purity≥98%
  • MDL No.MFCD09754023

*For research and further manufacturing use only, not for direct human use.

3-Aminopyrazin-2(1H)-one|CS-W019050

Structure of 43029-19-2

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General Information

  • CAS No. 43029-19-2
  • Cat. No. CS-W019050
  • Purity ≥98%
  • MDL No. MFCD09754023
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅N₃O
  • Molecular Weight 111.10
  • Synonym(s) 3-Aminopyrazin-2-ol
  • SMILES O=C1NC=CN=C1N

Description

3-Aminopyrazin-2(1H)-one delivers a versatile heterocyclic scaffold with enhanced solubility and hydrogen-bonding capacity, enabling efficient integration into bioactive molecules. This bench-stable compound features a polar amine group flanked by a nitrogen-rich ring system, facilitating robust interactions in medicinal chemistry applications.

Application

3-Aminopyrazin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyrazine-based heterocycles through straightforward functionalization. Its amine and carbonyl functionalities offer orthogonal reactivity for coupling reactions and derivatization, supporting applications in API development. The compound exhibits good bench stability and facilitates purification via standard chromatographic methods, making it well-suited for scalable synthetic workflows.

Synthesis

  • Route1

    References

    • Lee; Chello; Chou; Templeton; Parham Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 283 - 286
  • Route2
    • null|null
      156331-25-8
    • ~92%
    • In-stock
      3-Aminopyrazin-2(1H)-one|CS-W019050
      43029-19-2

    References

    • Sato; Matsuura; Miwa Synthesis, 1994 , # 9 p. 931 - 934

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   71.77
  • LogP   -0.6479
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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