Fmoc-NH-PEG4-CH2COOH

Name: Fmoc-NH-PEG4-CH2COOH
Brand: ChemScene
Availability: InStock
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CAS No. 437655-95-3
Cat. No. CS-0105401
Purity≥98%
MDL No.MFCD26142981

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Description

Fmoc-NH-PEG4-CH2COOH is a bifunctional linker featuring a fluorenylmethoxycarbonyl (Fmoc)-protected amine, a four-ethylene glycol (PEG4) spacer, and a terminal carboxylic acid. This structure enables efficient solid-phase synthesis of peptide-polymer conjugates and bioactive molecule immobilization. The PEG4 chain imparts solubility and reduces aggregation, while the Fmoc group allows for selective deprotection under mild basic conditions. The carboxylic acid facilitates coupling to primary amines via standard activation methods.

Application

Fmoc-NH-PEG4-CH2COOH serves as a versatile bifunctional linker for peptide synthesis and conjugation workflows. The Fmoc group enables orthogonal protection in solid-phase peptide synthesis, while the PEG4 spacer provides solubility and reduced aggregation. The terminal carboxylic acid facilitates coupling to amines via standard amide bond formation, making it ideal for preparing peptide-drug conjugates, protein bioconjugates, and functionalized resins with enhanced solubility and stability.

General Information

CAS No. 437655-95-3
Cat. No. CS-0105401
Purity ≥98%
MDL No. MFCD26142981
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₃₁NO₈
Molecular Weight 473.52
Synonym(s) None
SMILES O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCC(O)=O

Computational Chemistry Data

TPSA 112.55
LogP 2.6761
H_Acceptors 7
H_Donors 2
Rotatable_Bonds 16

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group PEG

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Linker Fmoc PEG

Life Science Linker PEG Acid

Life Science ADC Related Compound Cleavable Linker

Life Science PROTAC PROTAC Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

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Fmoc-NH-PEG4-CH2COOH

CAS No. 437655-95-3

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