Tert-butyl 5-amino-3-cyclopropyl-1H-pyrazole-1-carboxylate

Name: Tert-butyl 5-amino-3-cyclopropyl-1H-pyrazole-1-carboxylate
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CAS No. 437982-59-7
Cat. No. CS-0452516
Purity≥98%
MDL No.None

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Tert-butyl 5-amino-3-cyclopropyl-1H-pyrazole-1-carboxylate|CS-0452516

Structure of 437982-59-7

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General Information

CAS No. 437982-59-7
Cat. No. CS-0452516
Purity ≥98%
MDL No. None
Storage -20°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₇N₃O₂
Molecular Weight 223.27
Synonym(s) None
SMILES CC(C)(C)OC(=O)N1C(=CC(=N1)C2CC2)N

Description

Tert-butyl 5-amino-3-cyclopropyl-1H-pyrazole-1-carboxylate features a cyclopropyl group enhancing ring rigidity and lipophilicity, while the tert-butyl ester ensures stability and ease of deprotection. The amino substituent at C5 enables direct functionalization in late-stage diversification. This scaffold integrates readily into bioactive molecule design, particularly for kinase inhibitors and GPCR-targeted therapeutics.

Application

Tert-butyl 5-amino-3-cyclopropyl-1H-pyrazole-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyrazole scaffolds. The tert-butyl carbamate group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. The primary amine supports diverse transformations, including acylation, alkylation, and coupling reactions, while the cyclopropyl substituent enhances metabolic stability and modulates physicochemical properties. This compound functions effectively in standard synthetic workflows for constructing bioactive heterocycles.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07,GHS09
Signal Word : Warning	UN#: 3077
Class : 9	Packing Group : Ⅲ
Hazard Statements : H319-H410
Precautionary Statements : P264-P273-P280-P391-P501

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Computational Chemistry Data

TPSA 70.14
LogP 2.1259
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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Tert-butyl 5-amino-3-cyclopropyl-1H-pyrazole-1-carboxylate

CAS No. 437982-59-7

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