5-Chloro-2-methylpyrimidin-4-amine

Name: 5-Chloro-2-methylpyrimidin-4-amine
Brand: ChemScene
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CAS No. 438249-95-7
Cat. No. CS-0045639
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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5-Chloro-2-methylpyrimidin-4-amine|CS-0045639

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General Information

CAS No. 438249-95-7
Cat. No. CS-0045639
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₆ClN₃
Molecular Weight 143.57
Synonym(s) 4-Pyrimidinamine, 5-chloro-2-methyl- (9CI)
SMILES NC1=NC(C)=NC=C1Cl

Description

5-Chloro-2-methylpyrimidin-4-amine serves as a key heterocyclic scaffold in medicinal chemistry, featuring a chlorinated pyrimidine core with a methyl group at the 2-position and a primary amine at C4. This configuration enables efficient coupling reactions and enhances metabolic stability in bioactive molecule design. The compound demonstrates excellent solubility under standard conditions and exhibits robust bench-stability, facilitating its use in multi-step synthetic sequences.

Application

5-Chloro-2-methylpyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds through nucleophilic substitution and transition-metal-catalyzed coupling reactions. Its chlorine at C5 and amino group at C4 provide orthogonal reactivity for sequential functionalization, while the methyl group enhances metabolic stability. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for high-throughput synthesis and API development workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 51.8
LogP 1.02062
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

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5-Chloro-2-methylpyrimidin-4-amine

CAS No. 438249-95-7

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