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Structure of 445-04-5
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4-Amino-3-(trifluoromethyl)phenol features a strategically positioned trifluoromethyl group that enhances metabolic stability and lipophilicity, while the ortho-amino functionality enables direct coupling in Suzuki-Miyaura and Ullmann reactions. This bifunctional scaffold integrates readily into bioactive molecules, offering improved membrane permeability and resistance to oxidative degradation under standard bench conditions.
4-Amino-3-(trifluoromethyl)phenol serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds and functionalized arylamines. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the amino and phenolic functionalities offer orthogonal reactivity for coupling, acylation, and electrophilic substitution reactions. The compound exhibits good bench stability and is compatible with standard purification methods, facilitating integration into multi-step synthetic sequences.
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Lot numbers can be found on the outside label of a product: