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Structure of 445-13-6
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3-Chloro-4-(trifluoromethyl)aniline delivers a robust electron-deficient aromatic scaffold featuring a chloro group at the meta position and a strongly withdrawing trifluoromethyl moiety. This combination enhances electrophilic reactivity while maintaining bench-stable handling characteristics, enabling direct incorporation into pharmaceutical intermediates, agrochemicals, and functional materials via coupling reactions.
3-Chloro-4-(trifluoromethyl)aniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed coupling reactions. Its electron-deficient aryl core enhances reactivity in cross-coupling processes, while the chloro and trifluoromethyl groups provide orthogonal functional handles for downstream derivatization. Bench-stable and amenable to standard purification techniques, it functions reliably in multi-step syntheses requiring high functional group tolerance.
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H315-H319-H332
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: