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Structure of 446-30-0
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4-Chloro-2-fluorobenzoic acid features a strategically positioned carboxylic acid group flanked by chlorine and fluorine substituents, enabling precise electronic tuning. This electron-deficient aromatic scaffold integrates readily into pharmaceutical intermediates, offering enhanced metabolic stability and controlled reactivity under standard conditions.
4-Chloro-2-fluorobenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation of ortho-halogenated aromatic motifs into bioactive scaffolds. Its carboxylic acid group facilitates amide bond formation and esterification under standard conditions, while the complementary chlorine and fluorine substituents support palladium-catalyzed cross-coupling reactions. The molecule exhibits excellent bench stability and is readily purified by recrystallization, making it ideal for high-throughput synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: