2-Amino-4-fluorobenzoic acid

Name: 2-Amino-4-fluorobenzoic acid
Brand: ChemScene
Availability: InStock
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CAS No. 446-32-2
Cat. No. CS-W019810
Purity≥97%
MDL No.MFCD00075553

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

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Structure of 446-32-2

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Description

2-Amino-4-fluorobenzoic acid features a strategically positioned amino group and fluorine substituent on the benzene ring, enabling enhanced electronic modulation and metabolic stability. This combination facilitates direct incorporation into bioactive scaffolds, particularly in pharmaceutical intermediates and kinase inhibitor designs, where its dual functionality supports hydrogen bonding and targeted binding interactions under standard conditions.

Application

2-Amino-4-fluorobenzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-amino and meta-fluoro substituents offer complementary reactivity for palladium-catalyzed coupling, cyclization, and electrophilic substitution reactions. The compound exhibits good bench stability and facilitates straightforward purification via recrystallization, making it well-suited for scalable synthetic workflows.

General Information

CAS No. 446-32-2
Cat. No. CS-W019810
Purity ≥97%
MDL No. MFCD00075553
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆FNO₂
Molecular Weight 155.13
Synonym(s) None
SMILES O=C(O)C1=C(N)C=C(F)C=C1

Computational Chemistry Data

TPSA 63.32
LogP 1.1061
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Synthesis Synthetic Reagents Aryne Precursors, Heteroaryne Precursors Benzyne Precursors

Key Words

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2-Amino-4-fluorobenzoic acid

CAS No. 446-32-2

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