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CS-W001157 4
Total: USD 88.00

5-Bromo-N-methylpyrazin-2-amine

  • CAS No. 446286-92-6

  • Cat. No. CS-W022337
  • Purity≥97%
  • MDL No.MFCD09881407

*For research and further manufacturing use only, not for direct human use.

5-Bromo-N-methylpyrazin-2-amine|CS-W022337

Structure of 446286-92-6

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General Information

  • CAS No. 446286-92-6
  • Cat. No. CS-W022337
  • Purity ≥97%
  • MDL No. MFCD09881407
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆BrN₃
  • Molecular Weight 188.03
  • Synonym(s) 5-BROMO-2-(METHYLAMINO)PYRAZINE
  • SMILES CNC1=NC=C(Br)N=C1

Description

5-Bromo-N-methylpyrazin-2-amine features a bromine substituent at the 5-position and a methylamino group at nitrogen-2 of the pyrazine core, delivering enhanced electrophilicity and improved solubility in organic media. This combination enables efficient coupling reactions in late-stage functionalization and transition-metal-catalyzed transformations.

Application

5-Bromo-N-methylpyrazin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to access substituted pyrazine scaffolds. Its bromine moiety facilitates efficient C–C and C–N bond formation under standard conditions, while the N-methylpyrazin-2-amine core provides a stable, electron-deficient heterocyclic platform with favorable solubility and bench stability for downstream synthetic applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.81
  • LogP   1.2808
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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