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CS-W001157 4
Total: USD 88.00

2-(Trifluoromethyl)benzaldehyde

  • CAS No. 447-61-0

  • Cat. No. CS-W009016
  • Purity≥96%
  • MDL No.MFCD00003337

*For research and further manufacturing use only, not for direct human use.

2-(Trifluoromethyl)benzaldehyde|CS-W009016

Structure of 447-61-0

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General Information

  • CAS No. 447-61-0
  • Cat. No. CS-W009016
  • Purity ≥96%
  • MDL No. MFCD00003337
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₃O
  • Molecular Weight None
  • Synonym(s) o-(Trifluoromethyl)benzaldehyde; α,α,α-Trifluoro-o-tolualdehyde; 2-(Trifluoromethyl)benzaldehyde
  • SMILES O=CC1=C(C(F)(F)F)C=CC=C1

Description

2-(Trifluoromethyl)benzaldehyde has been used in the preparation of:-(dimethylamino)-alkylethyl-4(-2-(trifluorormethyl)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylatesmethyl (E)-2-[2-[(E)-2-(2-trifluoromethylphenyl)vinyl]-phenyl]-3-methoxyacrylate via Wittig-Horner reaction

Application

2-(Trifluoromethyl)benzaldehyde serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering a highly electron-deficient aromatic aldehyde with enhanced metabolic stability. Its trifluoromethyl group imparts strong lipophilicity and resistance to oxidative degradation, while the aldehyde functionality enables diverse transformations including nucleophilic additions, imine formations, and Wittig reactions. The compound exhibits excellent bench stability and is compatible with standard purification methods, facilitating its use in multi-step syntheses of bioactive heterocycles and functionalized aryl scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.5179
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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