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CS-W001157 4
Total: USD 88.00

3-Fluoro-4-methoxyphenol

  • CAS No. 452-11-9

  • Cat. No. CS-W005810
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-4-methoxyphenol|CS-W005810

Structure of 452-11-9

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Description

3-Fluoro-4-methoxyphenol features a fluorine atom at the meta position and a methoxy group at the para position relative to the phenolic hydroxyl, creating a uniquely polarized aromatic system. This configuration enhances solubility in organic solvents while maintaining stability under standard bench conditions. The compound serves as a key building block for bioactive molecule synthesis, particularly in pharmaceutical intermediates where modulated electron density and hydrogen-bonding capacity are critical.

Application

3-Fluoro-4-methoxyphenol serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds with enhanced metabolic stability. Its ortho-fluoro and para-methoxy substituents provide complementary reactivity for palladium-catalyzed cross-couplings and electrophilic substitutions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis in API development.

General Information

  • CAS No. 452-11-9
  • Cat. No. CS-W005810
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FO₂
  • Molecular Weight 142.13
  • Synonym(s) 2-Fluoro-4-hydroxyanisole
  • SMILES OC1=CC=C(OC)C(F)=C1

Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.5399
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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