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Structure of 452-11-9
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3-Fluoro-4-methoxyphenol features a fluorine atom at the meta position and a methoxy group at the para position relative to the phenolic hydroxyl, creating a uniquely polarized aromatic system. This configuration enhances solubility in organic solvents while maintaining stability under standard bench conditions. The compound serves as a key building block for bioactive molecule synthesis, particularly in pharmaceutical intermediates where modulated electron density and hydrogen-bonding capacity are critical.
3-Fluoro-4-methoxyphenol serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds with enhanced metabolic stability. Its ortho-fluoro and para-methoxy substituents provide complementary reactivity for palladium-catalyzed cross-couplings and electrophilic substitutions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: