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Structure of 452-64-2
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4-Fluoro-1,2-dimethylbenzene features a fluorine atom positioned para to a methyl group on a 1,2-dimethyl-substituted benzene ring. This electronic and steric configuration enhances its utility in synthetic organic chemistry, particularly for constructing electron-deficient aromatic systems under mild reaction conditions.
4-Fluoro-1,2-dimethylbenzene serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering a trifunctionalized aromatic scaffold with orthogonal reactivity. The fluorine substituent enables directed metallation and enhances metabolic stability, while the adjacent methyl groups provide steric guidance and serve as handles for further functionalization. This compound exhibits excellent bench stability and facilitates efficient late-stage derivatization via palladium-catalyzed cross-coupling or electrophilic substitution, making it a practical choice for modular library construction.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Warning
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226-H315-H319-H335
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P271-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P370+P378-P403+P233-P403+P235-P405-P501
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Lot numbers can be found on the outside label of a product: