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CS-W001157 4
Total: USD 88.00

O-Acetyl-N-[(1,1-dimethylethoxy)carbonyl]-L-threonine

  • CAS No. 45214-52-6

  • Cat. No. CS-B1738
  • Purity≥96%
  • MDL No.MFCD00151895

*For research and further manufacturing use only, not for direct human use.

O-Acetyl-N-[(1,1-dimethylethoxy)carbonyl]-L-threonine|CS-B1738

Structure of 45214-52-6

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General Information

  • CAS No. 45214-52-6
  • Cat. No. CS-B1738
  • Purity ≥96%
  • MDL No. MFCD00151895
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉NO₆
  • Molecular Weight 261.27
  • Synonym(s) None
  • SMILES CC(C)(C)OC(N[C@H](C(O)=O)[C@@H](C)OC(C)=O)=O

Description

O-Acetyl-N-[(1,1-dimethylethoxy)carbonyl]-L-threonine features a protected hydroxyl group and a stable carbamate moiety, enabling direct incorporation into peptide synthesis without side-chain activation. This bench-stable derivative simplifies the assembly of threonine-containing sequences under standard conditions.

Application

O-Acetyl-N-[(1,1-dimethylethoxy)carbonyl]-L-threonine serves as a protected amino acid building block for peptide synthesis, offering orthogonal protection of both amine and hydroxyl functionalities. The tert-butoxycarbonyl (Boc) group ensures stable N-protection under acidic conditions, while the acetyl moiety provides temporary O-protection compatible with standard deprotection protocols. Its bench-stable crystalline form facilitates handling and purification, enabling reliable incorporation into complex peptide sequences and heterocyclic scaffolds via established coupling methodologies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   101.93
  • LogP   0.9159
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   4

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