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CS-W001157 4
Total: USD 88.00

2,4-Difluoro-3-methoxybenzoic acid

  • CAS No. 178974-97-5

  • Cat. No. CS-0020088
  • Purity≥98%
  • MDL No.MFCD02258905

*For research and further manufacturing use only, not for direct human use.

2,4-Difluoro-3-methoxybenzoic acid|CS-0020088

Structure of 178974-97-5

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General Information

  • CAS No. 178974-97-5
  • Cat. No. CS-0020088
  • Purity ≥98%
  • MDL No. MFCD02258905
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆F₂O₃
  • Molecular Weight 188.13
  • Synonym(s) 2,4-Difluoro-3-methoxylbenzoic acid
  • SMILES O=C(O)C1=CC=C(F)C(OC)=C1F

Description

Biotin-PEG6-Mal is a maleimide biotinylation linker that can react with sulfhydryl groups (at pH 6.5-7.5) specifically to form a thioether linkage. The hydrophilic PEG spacer increases aqueous solubility of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the binding to avidin molecules.

Synthesis

  • Route1
    • null|null
      124-38-9
    • In-stock
      1,3-Difluoro-2-methoxybenzene|CS-W016398
      437-82-1
    • ~%
    • In-stock
      2,4-Difluoro-3-methoxybenzoic acid|CS-0020088
      178974-97-5

    References

    • WO2007/14308 A1, ; Page/Page column 65-66 ;
  • Route2
    • null|null
      124-38-9
    • In-stock
      2,6-Difluorophenol|CS-W013440
      28177-48-2
    • null|null
      74-88-4
    • ~51%
    • In-stock
      2,4-Difluoro-3-methoxybenzoic acid|CS-0020088
      178974-97-5

    References

    • Journal of Organic Chemistry, , vol. 71, # 26 p. 9845 - 9848
  • Route3
    • 1-Bromo-2,4-difluoro-3-methoxybenzene|CS-0195230
      221221-00-7
    • ~%
    • In-stock
      2,4-Difluoro-3-methoxybenzoic acid|CS-0020088
      178974-97-5

    References

    • US6329391 B1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.6716
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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