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Structure of 28314-80-9
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2,4,6-Trifluorobenzoic acid features a highly electron-deficient aromatic ring stabilized by three fluorine substituents, enabling efficient coupling reactions in synthetic chemistry. This bench-stable carboxylic acid integrates readily into pharmaceutical intermediates and functional materials, offering enhanced reactivity without requiring specialized handling conditions.
2,4,6-Trifluorobenzoic acid serves as a versatile building block in medicinal chemistry and materials science, enabling direct incorporation of multiple fluorine atoms into target molecules. Its high electrophilicity facilitates efficient amide and ester formation under standard coupling conditions, while the trifluoromethyl group enhances metabolic stability and lipophilicity. Bench-stable and readily purified by recrystallization, it functions reliably in diverse synthetic transformations including Suzuki-Miyaura cross-coupling and nucleophilic aromatic substitution.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: