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CS-W001157 4
Total: USD 88.00

2-Amino-1-(4-fluorophenyl)ethanone hydrochloride

  • CAS No. 456-00-8

  • Cat. No. CS-W020378
  • Molecule weight189.61
  • Purity≥96%
  • MDL No.MFCD00193059

*For research and further manufacturing use only, not for direct human use.

2-Amino-1-(4-fluorophenyl)ethanone hydrochloride|CS-W020378

Structure of 456-00-8

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General Information

  • CAS No. 456-00-8
  • Cat. No. CS-W020378
  • Purity ≥96%
  • MDL No. MFCD00193059
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClFNO
  • Molecular Weight 189.61
  • Synonym(s) 2-Amino-4'-fluoroacetophenone hydrochloride
  • SMILES FC1=CC=C(C=C1)C(CN)=O.[H]Cl

Description

2-Amino-1-(4-fluorophenyl)ethanone hydrochloride features a fluorinated aromatic ring paired with an amino ketone functionality, enabling direct incorporation into bioactive molecule scaffolds. This bench-stable salt form enhances solubility and handling in synthetic workflows, facilitating efficient access to pharmaceutical intermediates through straightforward derivatization pathways.

Application

2-Amino-1-(4-fluorophenyl)ethanone hydrochloride serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated phenethylamine derivatives. Its amino and ketone functionalities support diverse transformations, including reductive amination, condensation reactions, and heterocycle formation. The hydrochloride salt enhances bench stability and solubility, facilitating handling and purification in standard synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   1.3889
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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