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Structure of 456-56-4
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Trifluoromethylthiobenzene features a trifluoromethylthio group directly attached to a benzene ring, delivering enhanced electron-withdrawing character and improved metabolic stability. This moiety integrates readily into pharmaceutical scaffolds and functional materials, offering robust performance under standard reaction conditions.
Trifluoromethylthiobenzene serves as a valuable building block in synthetic organic chemistry, enabling direct introduction of the trifluoromethylthio (SCF₃) group—known for enhancing metabolic stability and lipophilicity in bioactive molecules. The compound exhibits good bench stability and functions as a versatile reagent in transition-metal-catalyzed coupling reactions, particularly in C–S bond formation and cross-coupling protocols. Its compatibility with diverse functional groups supports efficient synthesis of fluorinated aromatic scaffolds relevant to medicinal chemistry and agrochemical development.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226-H302-H315-H319-H335
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Precautionary Statements : P210-P261-P301+P330+P331-P302+P352
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Lot numbers can be found on the outside label of a product: