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Structure of 330-17-6
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4-((Trifluoromethyl)thio)benzoic acid features a para-trifluoromethylthio group that imparts strong electron-withdrawing character and enhanced lipophilicity, enabling efficient incorporation into bioactive scaffolds. This bench-stable carboxylic acid derivative facilitates direct coupling reactions in medicinal chemistry workflows without requiring activation steps.
4-((Trifluoromethyl)thio)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the introduction of a strongly electron-withdrawing trifluoromethylthio group at the para position of an aromatic ring. Its carboxylic acid functionality facilitates direct coupling reactions, amidation, esterification, and salt formation, while maintaining stability under standard bench conditions. The molecule exhibits good functional group tolerance and is particularly useful in constructing bioactive scaffolds where enhanced metabolic stability and lipophilicity are required.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: