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Structure of 458-45-7
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This 3-(3-fluorophenyl)propionic acid features a fluorinated aromatic ring linked via a propionic acid chain, offering enhanced metabolic stability and improved membrane permeability. The para-fluoro substitution imparts electron-withdrawing character, facilitating downstream functionalization in medicinal chemistry applications.
3-(3-Fluorophenyl)propionic acid serves as a versatile building block for pharmaceutical and agrochemical synthesis, enabling the construction of bioactive heterocycles and functionalized alkyl chains. Its fluorinated aromatic ring enhances metabolic stability and modulates lipophilicity, while the carboxylic acid group facilitates direct coupling reactions or derivatization under standard conditions. The compound exhibits excellent bench stability and is readily purified by recrystallization or chromatography, making it well-suited for iterative synthetic workflows in medicinal chemistry.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: