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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-methoxyaniline

  • CAS No. 458-52-6

  • Cat. No. CS-W007366
  • Purity≥96%
  • MDL No.MFCD00047827
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-methoxyaniline|CS-W007366

Structure of 458-52-6

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Description

2-Fluoro-4-methoxyaniline features a fluorine atom at the ortho position and a methoxy group at the para position relative to the amino functionality, delivering enhanced electron-donating character and improved metabolic stability. This substitution pattern enables efficient incorporation into pharmaceutical intermediates and advanced organic materials.

Application

2-Fluoro-4-methoxyaniline serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds. Its ortho-fluoro and para-methoxy substituents offer enhanced metabolic stability and modulated electronic properties. The amine group facilitates direct coupling reactions, while the molecule exhibits good bench stability and compatibility with standard purification methods.

General Information

  • CAS No. 458-52-6
  • Cat. No. CS-W007366
  • Purity ≥96%
  • MDL No. MFCD00047827
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FNO
  • Molecular Weight 141.14
  • Synonym(s) 4-Methoxy-2-fluoroaniline
  • SMILES C1=C(C(=CC=C1OC)N)F

Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.4165
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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