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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-methylpyridine

  • CAS No. 461-87-0

  • Cat. No. CS-W011273
  • Purity≥98%
  • MDL No.MFCD00041224

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-methylpyridine|CS-W011273

Structure of 461-87-0

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General Information

  • CAS No. 461-87-0
  • Cat. No. CS-W011273
  • Purity ≥98%
  • MDL No. MFCD00041224
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FN
  • Molecular Weight 111.12
  • Synonym(s) 2-Fluoro-4-picoline
  • SMILES CC1=CC(F)=NC=C1

Description

2-Fluoro-4-methylpyridine serves as a key heterocyclic building block in medicinal chemistry, featuring a fluorinated pyridine core with a methyl group at the 4-position. This combination imparts enhanced metabolic stability and modulates electronic properties for targeted drug design. The compound integrates readily into diverse synthetic pathways, enabling efficient access to bioactive molecules through coupling reactions and functional group interconversions.

Application

2-Fluoro-4-methylpyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine ring via palladium-catalyzed cross-coupling reactions. Its fluorinated and methyl-substituted structure provides enhanced metabolic stability and modulates electronic properties for targeted bioactive molecule synthesis. The compound exhibits excellent bench stability and compatibility with standard purification techniques, facilitating efficient incorporation into diverse heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1
    • null|null
      108-89-4
    • ~30%
    • In-stock
      2-Fluoro-4-methylpyridine|CS-W011273
      461-87-0

    References

    • Puy, Michael Van Der Tetrahedron Letters, 1987 , vol. 28, # 3 p. 255 - 258
  • Route2

    References

    • Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
  • Route3

    References

    • Shestopalov, Anatoliy M.; Fedorov, Alexander E.; Rodinovskaya, Liudmila A.; Shestopalov, Alexander A.; Gakh, Andrei A. Tetrahedron Letters, 2009 , vol. 50, # 37 p. 5257 - 5259

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.52912
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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