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Structure of 4623-24-9
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2-(3-Aminophenyl)acetonitrile features a strategically positioned nitrile group flanking an electron-rich aniline moiety, enabling direct incorporation into heterocyclic scaffolds. This bench-stable intermediate facilitates efficient coupling reactions and serves as a key building block in the synthesis of bioactive compounds, particularly in medicinal chemistry applications requiring modular nitrogen-containing frameworks.
2-(3-Aminophenyl)acetonitrile serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and functionalized aryl derivatives. Its ortho-aminobenzyl nitrile motif offers excellent compatibility with standard coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig protocols. The nitrile group facilitates downstream transformations to amides, carboxylic acids, or heterocycles, while the primary amine supports derivatization via acylation or alkylation. Bench-stable and readily purified by recrystallization or chromatography, it functions reliably in multi-step synthetic sequences.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: