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CS-W001157 4
Total: USD 88.00

4-(Aminosulfonyl)benzenesulfonyl chloride

  • CAS No. 46249-41-6

  • Cat. No. CS-0072200
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(Aminosulfonyl)benzenesulfonyl chloride|CS-0072200

Structure of 46249-41-6

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Description

4-(Aminosulfonyl)benzenesulfonyl chloride features a dual sulfonyl architecture with a terminal amine, enabling direct conjugation to biomolecules and polymers. This electrophilic reagent facilitates site-specific labeling under mild conditions, offering high reactivity toward nucleophiles while maintaining stability during storage.

Application

4-(Aminosulfonyl)benzenesulfonyl chloride serves as a versatile bifunctional building block for constructing sulfonamide-containing scaffolds. Its reactive sulfonyl chloride group enables efficient coupling with amines to form stable sulfonamide linkages, while the pendant aminosulfonyl moiety offers additional sites for derivatization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis in medicinal chemistry and API development workflows.

General Information

  • CAS No. 46249-41-6
  • Cat. No. CS-0072200
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClNO₄S₂
  • Molecular Weight 255.70
  • Synonym(s) 4-sulfamoylbenzenesulfonyl Chloride
  • SMILES O=S(C(C=C1)=CC=C1S(=O)(Cl)=O)(N)=O

Computational Chemistry Data

  • TPSA   94.3
  • LogP   0.2615
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group :
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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