Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile

  • CAS No. 4651-91-6

  • Cat. No. CS-W010759
  • Purity≥98%
  • MDL No.MFCD00128278

*For research and further manufacturing use only, not for direct human use.

2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile|CS-W010759

Structure of 4651-91-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 4651-91-6
  • Cat. No. CS-W010759
  • Purity ≥98%
  • MDL No. MFCD00128278
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀N₂S
  • Molecular Weight 178.25
  • Synonym(s) 2-AMINO-4,5-TETRAMETHYLENE-3-THIOPHENECARBONITRILE
  • SMILES N#CC1=C(N)SC2=C1CCCC2

Description

2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile features a fused heterocyclic core with a pendant amino group and electron-withdrawing nitrile functionality. This scaffold integrates readily into bioactive molecule design, offering enhanced solubility and metabolic stability. The compound serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and CNS modulators.

Application

2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its amino and nitrile functionalities enable diverse transformations, including amidation, cyclization, and metal-catalyzed coupling reactions. The saturated thiophene core provides structural rigidity and favorable physicochemical properties, while the molecule exhibits good bench stability and compatibility with standard purification methods.

Synthesis

  • Route1
    • null|null
      108-94-1
    • null|null
      109-77-3
    • ~99%
    • In-stock
      2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile|CS-W010759
      4651-91-6

    References

    • Zhao, Dan-Dan; Li, Li; Xu, Fan; Wu, Qi; Lin, Xian-Fu Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 95, p. 29 - 35
  • Route2

    References

    • Feroci, Marta; Chiarotto, Isabella; Rossi, Leucio; Inesi, Achille Advanced Synthesis and Catalysis, 2008 , vol. 350, # 17 p. 2740 - 2746
  • Route3
    • null|null
      108-94-1
    • ~%
    • In-stock
      2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile|CS-W010759
      4651-91-6

    References

    • Hu, Yi; Chen, Zhen-Chu; Le, Zhang-Gao; Zheng, Qin-Guo Synthetic Communications, 2004 , vol. 34, # 20 p. 3801 - 3806

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   49.81
  • LogP   2.08078
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4651-91-6 sigma4651-91-6 manufacturer4651-91-6 price4651-91-6 structure4651-91-6 SDSbuy 4651-91-64651-91-6 supplier4651-91-6 uses4651-91-6 molecular weightprice of 4651-91-64651-91-6 chemical name formula of 4651-91-6
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label