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CS-W001157 4
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3-Propan-2-yl-1,3-dihydroindol-2-one

  • CAS No. 4679-87-2

  • Cat. No. CS-0061058
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

3-Propan-2-yl-1,3-dihydroindol-2-one|CS-0061058

Structure of 4679-87-2

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Description

This indolone derivative features a sterically hindered isopropyl group at the 3-position, enhancing stability and modulating reactivity. The scaffold integrates readily into complex heterocyclic systems, offering a robust platform for medicinal chemistry exploration and synthetic diversification under standard conditions.

Application

3-Isopropyl-1,3-dihydroindol-2-one serves as a versatile scaffold in medicinal chemistry, enabling efficient access to indole-based heterocycles. Its functional group tolerance facilitates downstream derivatization via standard coupling and cyclization protocols. The isopropyl substituent enhances metabolic stability and modulates lipophilicity, improving bioavailability profiles. Bench-stable and readily purified by flash chromatography, it functions as a reliable building block for API intermediates and drug discovery campaigns.

General Information

  • CAS No. 4679-87-2
  • Cat. No. CS-0061058
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₃NO
  • Molecular Weight 175.23
  • Synonym(s) 3-isopropyloxindole
  • SMILES CC(C1C2=CC=CC=C2NC1=O)C

Computational Chemistry Data

  • TPSA   29.1
  • LogP   2.3783
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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