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Structure of 473923-95-4
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3-Fluoro-5-hydroxybenzonitrile features a strategically positioned hydroxyl group adjacent to a nitrile moiety, enabling direct functionalization in downstream synthetic transformations. The electron-withdrawing fluorine substituent enhances regioselectivity in electrophilic substitution reactions. This bench-stable, moisture-tolerant scaffold integrates readily into bioactive molecule design and serves as a key intermediate for pharmaceutical and agrochemical development.
3-Fluoro-5-hydroxybenzonitrile serves as a versatile building block for bioactive heterocycles and pharmaceutical intermediates. The ortho-fluoro and para-hydroxy groups enable directed metalation and electrophilic substitution, while the nitrile functions as a handle for amide, acid, or aldehyde transformations. Bench-stable and compatible with standard purification methods, it facilitates efficient synthesis of complex scaffolds in medicinal chemistry workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: