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CS-W001157 4
Total: USD 88.00

O-(tert-Butyldimethylsilyl)-L-homoserine

  • CAS No. 474023-97-7

  • Cat. No. CS-0132544
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

O-(tert-Butyldimethylsilyl)-L-homoserine|CS-0132544

Structure of 474023-97-7

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Description

O-(tert-Butyldimethylsilyl)-L-homoserine features a protected hydroxyl group enabling stable handling and compatibility with diverse synthetic protocols. This silyl ether derivative serves as a key intermediate in peptide and natural product synthesis, where selective deprotection facilitates late-stage functionalization. The tert-butyldimethylsilyl moiety provides robust protection under standard conditions while allowing orthogonal removal with fluoride sources.

Application

O-(tert-Butyldimethylsilyl)-L-homoserine serves as a key protected amino acid building block in peptide and heterocycle synthesis, offering enhanced stability and orthogonal protection. The silyl ether group enables selective deprotection under mild conditions, facilitating efficient manipulation of the hydroxyl functionality during multistep sequences. Its compatibility with standard coupling protocols and robustness toward common reaction conditions make it a practical choice for synthetic routes requiring precise functional group control.

General Information

  • CAS No. 474023-97-7
  • Cat. No. CS-0132544
  • Purity ≥95%
  • MDL No. None
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₃NO₃Si
  • Molecular Weight 233.38
  • Synonym(s) HomoSer(TBDMS)?-?OH
  • SMILES N[C@@H](CCO[Si](C)(C(C)(C)C)C)C(O)=O

Computational Chemistry Data

  • TPSA   72.55
  • LogP   1.8102
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   5

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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