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Structure of 478922-47-3
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This chiral pyrrolidine derivative features a hydroxymethyl group at the 5-position and a hydroxyl substituent at the 3-position, delivering enhanced solubility and metabolic stability. The hydrochloride salt form ensures improved crystallinity and handling convenience. This scaffold serves as a key building block in medicinal chemistry, particularly for targeted kinase inhibitors and CNS-active compounds.
(3R,5S)-5-(Hydroxymethyl)pyrrolidin-3-ol hydrochloride serves as a stereochemically defined pyrrolidine scaffold with orthogonal functional handles: a secondary alcohol and a primary aliphatic amine. The hydrochloride salt enhances solubility and stability in aqueous and polar organic media, enabling straightforward handling and purification. It functions as a versatile building block for medicinal chemistry campaigns, facilitating late-stage derivatization via reductive amination, esterification, or coupling reactions. Its well-defined stereochemistry supports consistent biological evaluation in target-directed synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: