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Ethyl 3-methoxy-1H-pyrazole-4-carboxylate

  • CAS No. 478968-48-8

  • Cat. No. CS-0135332
  • Purity≥96%
  • MDL No.MFCD13689107

*For research and further manufacturing use only, not for direct human use.

Ethyl 3-methoxy-1H-pyrazole-4-carboxylate|CS-0135332

Structure of 478968-48-8

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General Information

  • CAS No. 478968-48-8
  • Cat. No. CS-0135332
  • Purity ≥96%
  • MDL No. MFCD13689107
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂O₃
  • Molecular Weight 170.17
  • Synonym(s) None
  • SMILES O=C(OCC)C1=CNN=C1OC

Description

Ethyl 3-methoxy-1H-pyrazole-4-carboxylate features a pyrazole core with orthogonal functional handles: a methoxy group at C3 and an ethyl ester at C4. This combination enables selective derivatization in synthetic routes to bioactive heterocycles, offering enhanced solubility and stability under standard conditions.

Application

Ethyl 3-methoxy-1H-pyrazole-4-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyrazole scaffolds via palladium-catalyzed cross-coupling and nucleophilic displacement reactions. Its bench-stable nature, compatibility with diverse functional groups, and straightforward purification make it well-suited for medicinal chemistry campaigns and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   64.21
  • LogP   0.595
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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